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KMID : 1123920020160010160
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Korean Journal of Oriental Physiology and Pathology
2002 Volume.16 No. 1 p.160 ~ p.164
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Effects of the Fractionation of Sophorae Radix Water Extract on the Langendorff hearts
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Kim Sang-Beom
Kwon Kang-Beom
Park Jun-Su
Park Kwan-Ha
Ryu Do-Gon
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Abstract
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The water extract of Sophorae radix was tested for its preventive effects against cardiovascular anaphylaxis elicited in experimental animals. H₂O and ethyl acetate fractionation of Sophorae radix water extract improved anaphylactic cardiac dysfunction in passively sensitized isolated guinea hearts: improvement was noted in the maximal contractile force, post-challenge contractile force, post-challenge coronary flow and creatine kinase change elevation. These results suggest that H₂O and ethyl acute fractionation of Sophorae radix water extract possesses anti-anaphylactic effect in cardiovascular system.
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KEYWORD
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Sophorae radix, H₂O and ethyl acetate fractionation, cardiovascular anaphylaxis, anti-anaphylactic effect
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